Delivering Cures for Cancer is dedicated to fast tracking the availability of cures for cancer using new screening technologies and cancer-targeting, nanomedicine based delivery systems, which increases the effectiveness of drugs and eliminates toxic side effects, advancing the standard of cancer care for all. Delivering Cures for Cancer, was formerly known as The Paula Shore Sari Fox (PSSF) Foundation.
Behind Delivering Cures for Cancer: Human Interest Story Leads to Trailblazing Advances in Medical Technology
Paula Shore and Sari Fox were kind, loving and loyal mothers and wives. As matriarchs, they led by example, always put family first, and were active in their communities. They were vibrant, outgoing, and considered dear friends by all within their inner circles. They were trusted confidants, and their opinion was highly-valued. Meticulous, with sharp instincts, keen logic, and quick wit, Paula and Sari were a true tour de force. Their lives were filled with love, friendship and happiness, but ended far too soon.
Dr. Ronald Shore, Founder
Dr. Joseph Fox, Founder
Dr. Esther Chang, Principal Advisor
Professor Michio Kaku, Spokesman
Janine Shore, CEO
Paula Shore and Sari Fox: The Battles with Cancer that Led to the Delivering Cures for Cancer Foundation
Paula was the picture of perfect health. A petite woman, she ate right, exercised regularly, and was in amazing shape. It didn’t cross anyone’s mind that she could be plagued with sickness, but in February of 2005, everything changed. Paula noticed a lump on her back, which looked like a cyst. The lesion was biopsied, and the worst was revealed: it was advanced metastatic cancer. Further tests indicated the cancer had originated in her lungs, which was a terrible shock to Paula and her family, as she had smoked only for a short time early in her life, and had quit nearly 22 years earlier. Paula was entered into a promising chemotherapy study, but the optimistic outlook quickly turned sour as the cancer continued to spread. A second chemotherapeutic agent did no better, and instead of helping her combat the disease, it destroyed her white blood cells. She then entered a new vaccine study at NIH in Bethesda, MD but became so weak, she had to be hospitalized. The deterioration was dramatic and rapid. She lost a great deal of weight, she lost her hair, and she became so sensitive to light and sounds that she could no longer enjoy simple things like watching TV or going outside. She couldn’t eat, she couldn’t walk, and eventually, she lost her vision and her ability to talk because the cancer had spread to her brain. The effects were devastating and unfathomable.
And for Paula’s family, watching her suffer was unbearable. Her husband Ron had contacted 100 oncologists around the world to find a treatment and sent samples of his wife’s cancer cells to them to be tested for potentially helpful drugs, but to no avail. In an effort to save his wife, he spent endless hours studying articles on cancer research and alternate treatments. He lost 30 pounds and was in a devastated state.
It was equally painful and traumatic for Paula’s daughters to watch their mother deteriorate and endure the agony she dealt with on a daily basis. They felt helpless, cheated, and overwhelmed with grief. The disease had come out of nowhere, and because of her rapid deterioration, there simply wasn’t enough time to cope. Just weeks after preparing letters to all of her closest friends, thanking them for the many years of friendship they had shared and reassuring her family that it would be OK, Paula lost her fight on July 18, 2005 at the age of 56.
In spite of her tremendous suffering, Paula was the epitome of bravery. Never once did she ask the question, “Why me?”. Instead, she encouraged her family and faced death with dignity and strength, but she did have a dying wish: the wish was that one day, a cure for the dreadful disease that had stolen her life would be found so that others would not have to suffer like she did and endure the same fate.
In 2003 Sari was diagnosed with Stage IIIC ovarian cancer, and began a 7-year battle that included continual chemotherapy, several surgeries and many complications. Sari fearlessly pursued many different treatments: neoadjuvant therapy with experimental agents; debulking surgeries; and the administration of 18 different chemotherapy drugs. She called the chemotherapy her “toxic cure.”
Then, in 2008, Sari experienced sudden seizures that led to the discovery of an unusual metastasis of her ovarian cancer to the brain. She had immediate surgery to remove the tumor, and despite a long road to recovery, with speech and physical therapy, she persevered and returned to living life once again.
Two years later, however, in early summer 2010, Sari became noticeably weaker and experienced difficulty with her speech. An MRI revealed several inoperable brain metastases. Still wanting to fight this disease, she elected to have radiation in hopes of seeing a positive result.
Unfortunately, Sari and her family eventually ran out of options. Sari’s ability to fight her disease had weakened due to complications, and all that was left for the family to do was to find a way to make her as comfortable as possible. Sari’s husband and d
aughters, respected her decision to remain at home, and not be hospitalized. Sadly, in early September 2010, Sari passed away at home and in the company of those that loved her most. Through her courageous fight, Sari will forever be remembered as an amazing, brilliant, beautiful, wife ,and mother.
A Plea from the Daughters
We’ve all read articles or seen programs on TV about the devastating effects of cancer on a person, but until you’ve actually witnessed a family member suffer from cancer, you can’t ever truly understand just how devastating the disease truly is. There is simply nothing that can prepare you. Quite blatantly, it’s unfathomable. Even in spite of the staggering statistics on the number of lives that are affected and taken by cancer each year, many people live in the, “That’s really sad, but that will never happen to my family or me” mentality.
We know that mentality all too well because that’s how we thought. We never could have imagined that cancer would affect our families. We never expected to have to watch our mothers suffer the incredibly intense pain they did and deteriorate in the horrifically dramatic fashion we witnessed. And we never could have dreamed they would have been stolen away from us and we’d be left to face our lives without them. But that is exactly what became our reality.
Like our fathers, we didn’t want what our mothers went through to be in vain. That’s what the Delivering Cures for Cancer Foundation is all about. It is our deepest hope that the information, research, and treatment options available through the Foundation will help prevent others from experiencing what they did. Our goal is that this organization will make a change – a real change – to cancer treatment that will not only eliminate the barbaric process cancer patients currently have to endure, but save their lives, and, in effect, preserve their families.
Change and change for the better. That’s what we are promoting. Change to the treatments that are available to cancer patients — treatments that will target solely cancer cells and not fill their bodies with toxins; treatments that will not cause them to lose their hair; treatments that will not devastate their already weakened bodies even more. But we need your help to continue our research so that these treatments can be made available to people who desperately need them. Maybe that person is your friend. Maybe that person is a family member. Maybe that person is your mother. Please help us spread
this message for her sake.
Janine Shore, CEO
Background on the Nanomedicine Delivery System
Thanks to the pioneering work of world-renowned Nanotechnologist and Oncologist Dr. Esther Chang of Georgetown University, even those with advanced stage cancers stand a fighting chance of surviving. Dr. Chang has developed a treatment for advanced stage cancers that utilizes nanomedicine technology. What sets this treatment apart from any other treatment is that it delivers drugs specifically to cancer cells WITHOUT affecting normal cells. In animal studies, this treatment cured ALL OF THE MAJOR CANCERS without the typical toxic side effects that are so prevalent with traditional treatments (hair loss, severe nausea, etc.). Moreover, while drugs used to treat common side effects caused by current treatments typically cost thousands of dollars, with Dr. Chang’s treatment, no additional drugs would likely be required, thereby saving an inordinate amount of money. And this treatment could be made available soon. The only major obstacle standing in the way is the completion of FDA studies . . . which requires additional funding.
How does Tumor-Targeted Nanomedicine Work?
Dr. Chang’s nano-delivery system uses minute nanoparticles that not only accurately locate and attach to cells in primary tumors, but also target and attach to cancer cells that have metastasized to other parts of the body. The therapeutic agents carried by the nanoparticles are then transferred into the cancer cells, killing them. This tumor targeted delivery system not only greatly increases treatment effectiveness, but also enables healthy cells to be spared and eliminates harmful side effects.
New Early Screening Test for Cancer
Today, there is an early detection test that can identify lung cancer even when no symptoms are present! The test was developed by 20/20 GeneSystems, Inc. in Rockville MD, and is known as the PAULA’s Test. The name serves both as an acronym indicating the nature of the test (i.e. Protein Assays Using Lung Cancer Analytes), and to honor one of the Foundation’s namesakes, Paula Shore. Individuals or physicians interested in having the test may obtain additional information at www.paulastest.com.
Each year, 160,000 Americans die of lung cancer. Paula Shore was among them. She had a healthy lifestyle, and had undergone the screening tests appropriate for her gender and age. Unfortunately, she still contracted lung cancer. At the time, in 2005, there were no blood tests available to detect her cancer early when surgery could have saved her life. Paula Shore’s legacy lives on through groundbreaking new cancer screenings for early detection. It has been demonstrated that blood test biomarkers have detected evidence of lung cancer long before it was evident on x-ray studies.
If performed on patients annually, PAULA’s Test could detect cancer early, resulting in much more favorable survival rates.”
Early detection is something Dr. Shore has been advocating for a quarter of a century. At his dermatology practice, he has persuaded high risk patients to come in for check-ups every six months. The results? In over 25 years, not one person in the program has died from skin cancer or even had a close call:
The Skin Check Program – 1992 to Present
Over 20,000 skin examinations performed
Over 3,000 skin cancers detected
Over 100 melanomas detected
But NO DEATHS due to any skin cancers
Details of his program have been published in the Journal of Drugs in Dermatology: Drugs-Devices-Methods. 2011;10(3):244-252) and reported at major dermatology meetings. This article (in PDF) is provided with compliments by the Journal of Drugs in Dermatology (JDD).